CARBOXAMIDE DERIVATIVES OF PYRROLIDINE OR PIPERIDINE, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF INHIBITION OF PLATELET AGGREGATION Russian patent published in 2002 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel derivatives of pyrrolidine or piperidine of the formula (I) , their enantiomers and pharmaceutically acceptable salts: where R₁₀ means H or C(O)N(R¹)YZ; R₁ means H; Y means (CH₂)_p,(CH₂)_qCH(R³) or CH(R³)(CH₂)_q; R³ means aryl, aralkyl or heteroaryl; q = 1-3; p = 2 or 3; Z means CO₂H, CO₂-alkyl or 5-tetrazole; X means C(O); M means (CH₂)_m or piperidine-1-yl; m = 2; n = 2; R₅ means H; A is taken among piperidine-2-yl, piperidine-3-yl, piperidine-4-yl of N-substituted piperidine. Compounds of the formula (I) inhibit aggregation of platelets and can be used in medicine. EFFECT: improved method of inhibition, valuable medicinal properties. 5 cl, 6 tbl