PIPERAZINE COMPOUND, INHIBITOR OF PRODUCTION OF TNF (TUMOR NECROSIS FACTOR)-α AND/OR PROMOTER OF INDUCTION OF IL-10 (INTERLEUKIN-10) AND AGENT FOR PROPHYLAXIS OR TREATMENT BASED ON THEREOF Russian patent published in 2003 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention describes piperazine compound of the general formula (I) α or its pharmaceutically acceptable salt where and R¹ are similar or different and each mean hydrogen atom, halogen atom, lower alkyl, amino-group, amino-group substituted with monosubstituted lower acyl, nitro-group; R² are similar or different and each means hydrogen atom, halogen atom, lower alkyl, lower alkoxy-group, nitro-group, hydroxy- -group, amino-group mono- or disubstituted with group taken among group including lower alkyl or lower acyl; R³, R⁴, R⁵ and R⁶ are similar or different and each means hydrogen atom, acyl; R⁷ and R⁸ are similar or different and each means hydrogen atom or lower alkyl; Y means formula: R⁹ where and R¹⁰ mean hydrogen atom; R¹¹ and R¹² are similar or different and each means hydrogen atom or lower alkyl; or R¹³ and R¹² form in common alkylene; R¹³ and R¹⁴ mean hydrogen atom; m is a whole number 0-2; n is a whole number 0-2 and R¹⁵; cycle A means phenyl, pyrimidinyl, thiazolyl, pyridyl, pyrazolyl or imidazolyl. Invention describes also inhibitor of production of TNF-0≤m+n≤2 and/or promoter of production of IL-10 containing compound of the formula (I) or its pharmaceutically acceptable salt as an active component and agent used for prophylaxis and treatment of diseases induced by anomalous production of TNF-α, diseases mediated by TNF-α or diseases that can be treated with IL-10 and comprising compound of the formula (I) or its pharmaceutically acceptable salt as an active component. EFFECT: valuable medicinal properties of compounds. 22 cl, 2 tbl