DERIVATIVES OF HETEROARYLALKYLPIPERAZINE AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2005 - IPC

FIELD: organic chemistry, heterocyclic compounds, medicine, pharmacy.

SUBSTANCE: invention relates to derivatives of heteroarylalkylpiperazine of the general formula (I):

wherein m = 1, 2 or 3; q means NH or oxygen atom (O); R₁, R_2, R₃, R₄ and R₅ are taken independently among the group including hydrogen atom, (C₁-C₁₅)-alkyl, OR²⁰ wherein R²⁰ represents hydrogen atom; R₆, R₇ and R₈ represent hydrogen atom; R₉, R₁₀, R₁₁, R₁₂, R₁₃, R₁₄, R₁₅ and R₁₆ are taken independently among the group including hydrogen atom, (C₁-C₄)-alkyl; or R₉ and R₁₀ in common with carbon atom to which they are joined form carbonyl group; R₁₇ means heteroaryl that is taken among the group including indolyl, benzoxazolyl, benzothiazolyl, quinolinyl, isoquinolinyl, pyridyl, benzopyrazinyl substituted optionally with 1-2 substitutes taken among the group including hydrogen atom, CF₃ group, (C₁-C₈)-alkyl, phenyl, CON(R²⁰)₂. Compounds elicit property as a partial inhibitor of oxidation of fatty acids and can be used in therapy for protection of skeletal muscles against results of muscular or systemic diseases. Also, invention describes a pharmaceutical composition based on the claimed compounds.

EFFECT: valuable medicinal properties of compounds.

39 cl, 3 tbl, 25 ex