DERIVATIVES OF TRIPHENYLETHYLENE, METHODS OF TREATMENT AND PROPHYLAXIS OF OSTEOPOROSIS, BREAST CANCER AND CARDIOVASCULAR DISEASE Russian patent published in 2003 - IPC

FIELD: organic chemistry, medicine. SUBSTANCE: invention describes derivatives of triphenylethylene of the general formula (I): where R¹ means or ; R² and R³ mean H; R⁴ means ; R⁵ and R⁶ mean independently H, -alkyl; R⁷ means +CN, -alkyl-OH, , -alkyl-NR¹⁰R¹¹, or oxadiazole substituted with methyl; R⁸ and R¹⁰ mean -alkyl; R¹⁰ and R¹¹ mean independently methyl or ethyl; R¹², R¹³ mean -alkyl; X means oxygen atom; n means a whole number taken among 0, 1 or 2; m means a whole number 1 or 2; p means a whole number from 1 to 4 under condition that when R⁴ means then both do not mean hydrogen atom. Invention describes also methods of treatment and prophylaxis of osteoporosis, breast cancer and cardiovascular disease. Invention provides synthesis of novel compounds eliciting the useful biological properties. EFFECT: valuable medicinal properties of compounds. 15 cl, 2 dwg, 1 tbl, 27 ex