SUBSTITUTED DIALKYL (OXIDE)-Λ-SULFANILIDENE NICOTINAMIDE DERIVATIVES AS KINASE INHIBITORS Russian patent published in 2020 - IPC C07D405/14 C07D213/82 C07D405/12 C07D409/14 C07D401/12 C07D413/12 A61K31/44 A61K31/443 A61K31/4439 A61P35/00 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula I

or a pharmaceutically acceptable salt thereof, where Z is

or ,

where X is absent, or X is selected from a group consisting of NH and CH₂; R is selected from a group consisting of hydrogen, amino and lower alkyl, R¹ is selected from a group consisting of hydrogen and halogen, R² is hydrogen, R³ and R⁴ are independently selected from a group consisting of hydrogen, C₁-C₈ alkyl, (CR⁵R⁶)_aC(O)OR⁷, (CR⁵R⁶)_aOR⁷, (CR⁵R⁶)_aC(O)N(R⁷)₂, (CR⁵R⁶)_aN(R⁷)₂, wherein N(R⁷)₂ can be taken together to form 3–7-member heterocyclic ring optionally substituted with one or more R⁵, wherein, if one of R³ and R⁴ is (CR⁵R⁶)_aC(O)OR⁷, the other can not be (CR⁵R⁶)_aC(O)OR⁷; or R³ and R⁴ can be taken together with a sulfur atom to form 4–7-member heterocyclic ring optionally substituted with one or more R⁹, R⁵ is selected from a group consisting of hydrogen, hydroxy and CH₂CH₂OCH₂CH₂OH; R⁶ is hydrogen; R⁷ is selected from a group consisting of hydrogen, C₁-C₈ alkyl, fluorine; R⁹ is selected from a group consisting of hydrogen, C₁-C₈ alkyl; Ar¹ and Ar² are independently selected from a group consisting of

, , , , , ,

where R⁸ is selected from a group consisting of hydrogen, C₁-C₄ alkyl, amino, hydroxyl, alkoxy, halogen and CF₃, and equals 0 or integer from 1 to 4.

EFFECT: compounds are able to modulate the tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

19 cl, 10 tbl, 42 ex