FIELD: medicine. SUBSTANCE: invention relates to method of attenuation, treatment or prophylaxis of drug-mediated respiratory depression, muscle rigidity or nausea/emesis in animal associated with administration in indicated animal of the mixed delta/mu-opioid agonist or drug mediates respiratory depression. Method involves administration in animal receiving indicated drug the effective dose of compound as agonist of delta- -receptor of the formula (I) 
. Method allows to reduce the indicated respiratory depression, muscle rigidity or nausea/emesis with enhanced effectiveness. EFFECT: improved methods, enhanced effectiveness of compositions. 19 cl, 2 dwg
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