ORGANIC COMPOUNDS Russian patent published in 2022 - IPC A61K31/4985 A61P25/00 

FIELD: medicine.

SUBSTANCE: invention relates to a method for the treatment or prevention of a disorder of the central nervous system, including the administration to a patient who needs it of a compound of the formula I:

Formula I,

in which: X is -NH-; L is O; Z is -CH(O-R₁)-, -O-, or -C(O)-; R₁ is H; in a free or pharmaceutically acceptable salt form. In this case, the disorder is a pain disorder selected from neuropathic pain, idiopathic pain, chronic pain, fibromyalgia, toothache, and traumatic pain; or the disorder is a pain disorder in a patient also suffering from a gastrointestinal and/or pulmonary disorder, or in a patient also suffering from a disorder related to opioid use; or the disease or disorder is opiate overdose or a disorder related to opioid use. The invention also relates to the use of the specified compound in the production of a drug for the treatment or prevention of disorders of the central nervous system, where the disorder is selected from the above-mentioned.

EFFECT: treatment method is developed, including the administration of a compound of the formula I for the treatment or prevention of the above-mentioned disorders.

16 cl, 2 dwg, 17 ex