FIELD: medicine, pharmacy, fungicides. SUBSTANCE: composition has core and envelope. Core has the following components, wt.%: nistatin, 30.0-58.0; gelatin, 0.5-5.0; starch, 13.8-36.0; lactose, 25.0-38.2; stearic acid, 0.2-1.0; and talc, 0.3-3.0. Envelope consists of methylcellulose derivative, Tween-80, titanium dioxide, silicon emulsion KE 10-12, vanillin and dye. Preferably, envelope has the following components, wt.%: methylcellulose or hydroxypropylcellulose, 55.8-92.0; Tween-80, 2.0-21.4; titanium dioxide, 1.0-15.0; silicon emulsion KE 10-12, 0.8-5.8; vanillin, 0.3-5.6; and dye, 0.1-1.0. Composition can be made as tablet. Method of preparing the composition involves mixing nistatin with vehicle (mixture of starch with lactose), wetting obtained mass with gelatin an aqueous solution. Mass ratio gelatin : mass to be wetted = 1:(0.9-1.9). The following stages involve drying, powdering with mixture of starch, stearic acid and talc, formation of granules and envelope applying. Preferably, 5.0-11.0% of starch mass in medicinal form is added in composition of powdering agent and the rest part in vehicle composition. Obtained composition is stable in storage, releases active component easily that provides its high bioavailability. Invention can be used for treatment of fungal diseases and for prophylaxis and treatment of fungal complications after antibacterial therapy carrying out. EFFECT: enhanced effectiveness of composition, improved method of preparing. 6 cl, 1 tbl, 5 ex
