COMPOSITION WITH PROLONGED EFFECT POSSESSING ANTI-HYPERTENSIVE AND DIURETIC ACTIVITY AND METHOD FOR ITS PREPARING Russian patent published in 2006 - IPC A61K31/4045 A61K9/32 A61J3/10 A61P9/12 A61P7/10 

FIELD: medicine, chemical-pharmaceutical industry, pharmacy.

SUBSTANCE: invention proposes a composition possessing anti-hypertensive and diuretic activity with prolonged release of an active component. The composition comprises an envelope-covered core comprising indapamide as an active component and ludipress, hydroxypropylmethylcellulose, aerosil and stearate as accessory components. The core is covered by a film-forming envelope that is based on hydroxypropylmethylcellulose preferably and comprising additionally polyethylene glycol, glycerol, talc, titanium dioxide and lactose. Method for preparing the novel composition involves mixing indapamide and accessory components followed by forming the prepared mixture to form the core of required configuration and size and applying the envelope. The composition is characterized by continuous release of indapamide, high fracture and abrasion strength, stability of active component during storage with the fitness time above 2 years.

EFFECT: improved preparing method, improved and valuable properties of composition.

9 cl, 2 tbl, 4 ex