INHIBITORS OF PRENYLTRANSFERASES Russian patent published in 2003 - IPC

FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention relates to compounds of the formula (I) or the formula (II) where R₁ means N(R₁₀)(R₁₁); R₂ means lower thioalkyl; each of R₃ and R₅ means independently CH₂ or C(O); R₄ means unsubstituted or substituted lower thioalkyl where CH₂NHC(O)R₁₃ is a substituent and it is linked to the indicated thio-group; R₆ means a residue of heteroaromatic α-amino acid; R₇ means a residue of natural or synthetic α-amino acids; R₈ means OH or lower alkoxy-group or in common with R₇ it forms homoserine lactone; R₉ means H; each of R₁₀ and R₁₁ represents independently H; R₁₂ means unsubstituted or substituted fragment taken among aryl, aryl-lower alkyl where one or some lower alkyls or halogen atom are substituents; R₁₃ means lower alkyl; R₁₈ means H under condition that if R₄ means unsubstituted lower thioalkyl then free thio-groups from R₂ and R₄ can form disulfide bond; or its pharmaceutically acceptable salts. Compounds elicit ability to inhibit activity of prenyltransferases. Invention describes also pharmaceutical compositions comprising indicated compounds and method of inhibition of activity of prenyltransferase. EFFECT: valuable biochemical properties of compounds. 22 cl, 3 ex