DERIVATIVES OF IMIDAZOLE, PHARMACEUTICAL COMPOSITION, AND METHODS FOR INHIBITION OF ACTIVITY OF FARNESYL PROTEIN TRANSFERASE AND PRENYLTRANS- FERASE AND SUPPRESSION OF TUMOR GROWTH Russian patent published in 2003 - IPC

FIELD: organic chemistry, biochemistry, medicine, oncology. SUBSTANCE: invention relates to novel derivatives of imidazole of the formulas (I) and (II) wherein l, m, r, s and t = 0 or 1; n = 1 or 2 under condition that when l and m = 0 then n = 2; Y means SO₂ or CH₂; Z means CR¹²,NR³²SO₂,NR¹³,NR³⁶CO,OCONR¹⁵,SO₂NR¹⁴; R₁ is taken among the group consisting of hydrogen atom, alkyl or aralkyl and symbol means a simple or double bond; R⁷,R⁸ are taken among the group consisting of hydrogen atom, aryl, -CN, halide and U-R⁴⁴ where U means oxygen atom; R⁴⁴ and R¹¹ are taken among the group consisting of hydrogen atom, alkyl, aralkyl, aryl; R³² is taken among the group consisting of hydrogen atom, unsubstituted lower alkyl or lower alkyl substituted with phenyl and thienyl; R⁹,R¹⁰,R¹²,R¹³,R¹⁴,R¹⁵,R³⁶,R³⁷,R³⁸ represent hydrogen atom or lower alkyl; one of R, S and T represents CH₂ or CH(CH₂)_pQ where Q means NR⁵⁷R⁵⁸ wherein p = 0, 1 or 2 under condition that when Y means SO₂ then R¹¹ can not mean hydrogen atom. Invention relates also to its enantiomers, diastereomers, pharmaceutically acceptable salts and solvates. Invention relates also to pharmaceutical composition based on these compounds, methods for inhibition of activity of farnesyl protein transferase and prenyltranseferase and inhibition of the tumor growth. Invention provides preparing novel derivatives of imidazole eliciting inhibitory activity with respect to farnesyl protein transferase and prenyl- transferase and usable for suppression of growth of tumors. EFFECT: improved inhibition methods, valuable medicinal properties of compounds. 14 cl, 1 tbl, 30 ex