NOVEL SULFUR-CONTAINING DERIVATIVES WITH AMIDE LINKAGE, METHOD OF THEIR SYNTHESIS, THEIR USING AS MEDICINE AND PHARMACEUTICAL COMPOSITION Russian patent published in 2003 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to compounds that can be used as medicines eliciting inhibitory effect on endothelin-converting enzyme. Invention relates to compounds of the formula (I): where n = 0 or 1; R₁ means, in part, phenyl or biphenyl that can be substituted if necessary, in part, with benzyloxy- -group, dioxol or halogen atom; R₂ means, in part, hydrogen atom ot methyl substituted, in part, with indolyl, phenylthio-group or phenyl that can be substituted if necessary; A means carboxy-group, tetrazolyl or substituted alkyl and to also all salts and isomers of compounds of the formula (I). Invention can be used in treatment of diseases caused by anomalous high levels of endothelin. EFFECT: improved method of synthesis, valuable medicinal properties of compounds and pharmaceutical compositions. 9 cl, 1 tbl, 29 ex