FIELD: pharmacy, biochemistry. SUBSTANCE: invention relates to rapidly dissolving pharmaceutical composition that is able to inhibit activity of aldose reductase. Composition comprises a micronized (R)- 2-(4-bromo-2-fluorobenzyl)-1,2,3,4-tetrahydropyrrolo[1,2-a] -pyrazine-4-spiro-3'-pyrrolidine-1,2', 3,5'- tetrone (AS-3201) in the dose about 0.5-25 wt.-%. Mean size of particles of micronized powder AS-3201 is less 20 mcm. Pharmaceutical composition exhibits the improved indices of dissolving in combination with good bioavailability. Part of active substance AS-3201 dissolving is 50% or above for 15 min after onset of testing for dissolving. EFFECT: improved and valuable properties of composition. 12 cl, 1 dwg, 2 tbl
| Title |
Year |
Author |
Number |
| DISINTEGRATING AGENT |
1999 |
- Murakami Tosio
- Ii Noritaka
- Sakurai Khirojuki
|
RU2201215C2 |
| QUICKLY DECOMPOSING, PRESSED IN FORMS MATERIALS AND METHOD OF THEIR PREPARING |
1997 |
- Murakami Tosio
- Aritomi Khideaki
- Ueno Naoto
|
RU2189227C2 |
| (R)-5-BROMO-N-ETHYL-4-METHYLHEXAHYDRO-1H-1,4-DIAZEPIN-6- YL)-2-METHOXY-6 METHYLAMINO-3-PYRIDINECARBOXAMIDE, METHOD OF PREPARATION THEREOF, PHARMACEUTICAL COMPOSITION AND ANTIEMETIC AGENT COMPRISING SAID COMPOUNDS, AND INTERMEDIATE COMPOUND THEREOF |
1996 |
- Siro Kato
- Esimi Khirokava
- Tosija Morie
- Khirosi Kharada
- Naojuki Esida
|
RU2156248C2 |
| PHARMACEUTICAL COMPOSITIONS |
2006 |
|
RU2398586C2 |
| DERIVATIVES OF 6-METHOXY-1H-BENZOTRIAZOLE-5-CARBOXAMIDE, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF |
1995 |
- Siro Kato
- Esimi Khirokava
- Khirosi Jamazaki
- Tosija Mori
- Naojuki Esida
|
RU2141958C1 |
| DERIVATIVES OF 5-SUBSTITUTED-3-OXADIAZOLYL-1,6-NAPHTHYRIDINE-2(1H)-ONE, PHARMACEUTICAL COMPOSITION AND DERIVATIVES OF 1,6-NAPHTHYRIDINE-2(1H)-ONE |
1998 |
- Okhno Kazunori
- Odai Osamu
- Masumoto Kaoru
- Furukava Kijosi
- Oka Makoto
|
RU2188199C2 |
| VITREOUS FORM OF 8-[3-[N-[E]-3-(6-ACETAMIDOPYRIDIN-3-YL)ACRYLOYLGLYCYL]-N- METHYLAMINO]-2,6-DICHLORO-BENZYLOXY]-2-METHYLQUINOLINE, METHOD OF ITS PREPARING AND PHARMACEUTICAL COMPOSITION |
1999 |
- Okhnisi Norio
- Aoki Osamu
- Okhike Atsuo
- Okimoto Kazuto
- Isikuro Khirosi
|
RU2202550C2 |
| SOLID PREPARATION OF HIGH ABSORPTION |
2001 |
- Kataoka Katsuo
- Kikuti Khirosi
- Suzuki Tatsuja
- Simaja Takakhiro
- Kobajasi Khideo
- Kurosava Akira
- Isido Koiti
|
RU2287328C2 |
| TABLET WITH THE SLOWED DOWN LIBERATION, CONTAINING A ALFUZOSIN HYDROCHLORIDE |
2010 |
- Aukh Dzhin
- Kim Chan-Khvan
- Khan Chan-Kjun
- Dzhehon Khjon-Gun
- Kim Jan-Dzhoon
- Kim Dzhon-Gehal
- Park Dzhun-Ki
|
RU2442570C1 |
| MEDICINAL AGENTS USED FOR PROPHYLAXIS AND TREATMENT OF NEURODEGENERATIVE DISEASES |
2001 |
- Furukava Kiesi
- Kurumija Satosi
- Okimoto Kazuo
- Okhno Kazunori
|
RU2258506C2 |
