(R)-5-BROMO-N-ETHYL-4-METHYLHEXAHYDRO-1H-1,4-DIAZEPIN-6- YL)-2-METHOXY-6 METHYLAMINO-3-PYRIDINECARBOXAMIDE, METHOD OF PREPARATION THEREOF, PHARMACEUTICAL COMPOSITION AND ANTIEMETIC AGENT COMPRISING SAID COMPOUNDS, AND INTERMEDIATE COMPOUND THEREOF Russian patent published in 2000 - IPC

Abstract RU 2156248 C2

FIELD: chemical industry. SUBSTANCE: described is new compound of formula I: or physiologically acceptable acid addition salts thereof. Compound shows potent antagonistic activities to receptor of S3 serotonin and D2 dopamine. Also described are method of preparing said compound, and pharmaceutical and antiemetic agent based on said compound and intermediate compound thereof. EFFECT: improved properties of the title compound. 8 cl, 4 tbl

Similar patents RU2156248C2

Title Year Author Number
DERIVATIVES OF 6-METHOXY-1H-BENZOTRIAZOLE-5-CARBOXAMIDE, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF 1995
  • Siro Kato
  • Esimi Khirokava
  • Khirosi Jamazaki
  • Tosija Mori
  • Naojuki Esida
RU2141958C1
ACETAMIDE DERIVATIVES (VARIANTS), METHOD OF PREPARATION THEREOF (VARIANTS), PHARMACEUTICAL COMPOSITION AND AGENT 1996
  • Teruja Murata
  • Kehtsukhiko Khino
  • Kiesi Furukava
  • Makoto Oka
  • Mari Itokh
RU2160256C2
DERIVATIVE OF 3-OXADIAZOLYL-5,6,7,8-TETRAHYDRO-1,6-NAPHTIRIDINE AND DERIVATIVE OF 5,6,7,8-TETRAHYDRO-1,6-NAPHTIRIDINE 1993
  • Kazunori Okhno[Jp]
  • Osamu Odai[Jp]
  • Jukio Tominaga[Jp]
  • Kijosi Furukava[Jp]
  • Makoto Oka[Jp]
RU2107686C1
DERIVATIVES OF PYRIDONE CARBOXYLIC ACID, METHODS OF THEIR SYNTHESIS, ANTITUMOR AGENT AND PHARMACEUTICAL COMPOSITION 1995
  • Tomita Kodzi
  • Tiba Katsumi
  • Kasimoto Sigeki
  • Sibamori Kokh-Itiro
  • Tsuzuki Jasunori
RU2151770C1
INDOLE DERIVATIVE 1995
  • Siro Kato
  • Khirosi Kharada
  • Josimi Khirokava
  • Naojuki Josida
  • Khitosi Kavasima
RU2137759C1
DERIVATIVES OF 1-[ω-(3,4-DIHYDRO-2-NAPHTHALINYL)ALKYL]- -CYCLIC AMINE AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF 1996
  • Naoki Kaj
  • Aki Kanekhira
  • Tosija Morie
  • Katsukhiko Khino
  • Katsuesi Kavasima
  • Isao Simizu
  • Kazukhisa Akijama
RU2142453C1
PHENYLACETIC ACID COMPOUNDS 2008
  • Naganava Atsusi
  • Nagase Tosikhiko
RU2470926C2
DERIVATIVES OF 5-SUBSTITUTED-3-OXADIAZOLYL-1,6-NAPHTHYRIDINE-2(1H)-ONE, PHARMACEUTICAL COMPOSITION AND DERIVATIVES OF 1,6-NAPHTHYRIDINE-2(1H)-ONE 1998
  • Okhno Kazunori
  • Odai Osamu
  • Masumoto Kaoru
  • Furukava Kijosi
  • Oka Makoto
RU2188199C2
METHOD OF PRODUCING DERIVATIVES OF 1,8-NAPHTHIRIDINE OR SALTS THEREOF 0
  • Dzyun-Iti Matsumoto
  • Siniti Nakamura
  • Teruyuki Miyamoto
  • Khitosi Uno
SU1445558A3
MEDICINAL AGENTS USED FOR PROPHYLAXIS AND TREATMENT OF NEURODEGENERATIVE DISEASES 2001
  • Furukava Kiesi
  • Kurumija Satosi
  • Okimoto Kazuo
  • Okhno Kazunori
RU2258506C2

RU 2 156 248 C2

Authors

Siro Kato

Esimi Khirokava

Tosija Morie

Khirosi Kharada

Naojuki Esida

Dates

2000-09-20Published

1996-07-23Filed