FIELD: organic chemistry, medicine, psychiatry, pharmacy.
SUBSTANCE: invention relates to medicinal agents used for prophylaxis and treatment of schizophrenia by inhibition or suppression of neurodegenerative disease caused by hypofunction of glutamic acid receptors. As an active component agents comprise derivative of 5-substituted 3-oxadiazolyl-1,6-naphthiridine-2(1H)-one of the formula (I):
wherein Het represents oxadiazolyl group; R1 represents hydrogen atom, lower alkyl group, lower cycloalkyl group, trifluoromethyl group, lower alkenyl group, lower alkynyl group, lower alkoxyl group, lower alkoxy-(lower)-alkyl group, lower hydroxyalkyl group, substituted or unsubstituted aryl group, substituted or unsubstituted heteroaryl group; R2 represents hydrogen atom, lower alkyl group, lower cycloalkyl group, lower cycloalkylmethyl group, lower alkenyl group, lower cycloalkenyl group, lower alkynyl group, substituted or unsubstituted aryl group and substituted or unsubstituted heteroaryl group wherein indicated groups represent phenyl or naphthyl and indicated heteroaryl groups represents furyl, thienyl or pyridyl, or their physiologically acceptable acid-additive salts.
EFFECT: valuable medicinal properties of agents.
10 cl, 1 tbl
Title | Year | Author | Number |
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DERIVATIVES OF 5-SUBSTITUTED-3-OXADIAZOLYL-1,6-NAPHTHYRIDINE-2(1H)-ONE, PHARMACEUTICAL COMPOSITION AND DERIVATIVES OF 1,6-NAPHTHYRIDINE-2(1H)-ONE | 1998 |
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DERIVATIVE OF 3-OXADIAZOLYL-5,6,7,8-TETRAHYDRO-1,6-NAPHTIRIDINE AND DERIVATIVE OF 5,6,7,8-TETRAHYDRO-1,6-NAPHTIRIDINE | 1993 |
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RU2329044C1 |
2-ALKYLAMINO-3-ARYLSULPHONYLCYCLOALKANO [e OR d]PYRAZOLO[1,5-a] PYRIMIDINES SEROTONIN 5-HT RECEPTOR ANTAGONISTS, METHODS FOR MAKING AND APPLYING THEREOF | 2008 |
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Authors
Dates
2005-08-20—Published
2001-06-12—Filed