METHOD OF ISOLATION AND PURIFICATION OF BUDESONIDE Russian patent published in 2003 - IPC

Abstract RU 2203953 C2

FIELD: medicine, pharmacy. SUBSTANCE: invention relates to method of isolation and purification of budesonide that is highly effective hormonal broncholytic agent. Isolation of crude budesonide from cultural fluid is carried out at pH value 2-2.5 and budesonide is extracted from precipitated mixture of steroid and cultural biomass with ethyl acetate in the ratio budesonide : ethyl acetate = 1 : (20-28), respectively. Recrystallization of budesonide is carried out after preliminary soaking crude budesonide in ethyl acetate in the ratio = 1 : (1.9-2.1), respectively. Proposed method of isolation and purification of budesonide allows to obtain budesonide satisfying for all requirements of pharmacopoeia article, to reduce ethyl acetate consumption by 8-10 times, to enhance the yield of pharmacopoeia budesonide by 8-9%. EFFECT: improved method of isolation and purification of budesonide. 2 cl, 2 ex

Similar patents RU2203953C2

Title	Year	Author	Number
METHOD OF 11β-HYDROXYSTEROID SYNTHESIS	1989	Demchenko В.I. Domrachev N.V. Кrymov А.Р. Gireva N.N. Мart'Janova V.N. Navtsenja L.G. Naumova G.А. Тjuljaev I.I. Vajsman Е.М.	SU1656870A1
11,21-DIACETATE (22RS)-16α,17α-BUTYLIDENEDIOXY-1111β, 21-DIHYDROXYPREGNA-1,4-DIENE-3,20-DIONE AS INTERMEDIATE PRODUCT IN SYNTHESIS OF BUDECONIDE	1989	Gireva N.N. Demchenko В.I. Кrymov А.Р. Navtsenja L.G. Naumova G.А. Мart'Janova V.V. Domrachev N.V. Shashkina L.F. Sherman F.В. Кarina L.М.	SU1660379A1
METHOD FOR PREPARING 6α-METHYLHYDROCORTISONE	2006	Lukashev Nikolaj Vadimovich Kazantsev Aleksej Vital'Evich Savinova Tat'Jana Stepanovna Arinbasarova Anna Jur'Evna	RU2297423C1
METHOD OF ANDROST-4-EN-3,17-DIONE ISOLATION	1988	Grinenko G.S. Popova E.V. Popova N.I. Ryzhkova V.M. Skvortsova L.F.	RU1612585C
METHOD OF OBTAINING 6α-METHYLHYDROCORTISONE OR ITS 11β-ALKANOYLOXY-DERIVATIVES (VERSIONS), METHOD OF OBTAINING 6α-METHYLPREDNISOLONE OR ITS 11β-ALKANOYLOXY-DERIVATIVES USING OBTAINED 6α-METHYLHYDROCORTISONE OR ITS 11β-ALKANOYLOXY-DERIVATIVES	2006	Savinova Tat'Jana Stepanovna Kazantsev Aleksej Vital'Evich Lukashev Nikolaj Vadimovich Arinbasarova Anna Jur'Evna Stepanov Anatolij Ivanovich Skrjabin Georgij Andreevich	RU2337918C9
METHOD OF OBTAINING 11BETA, 17 ALPHA, 21-TRIHYDROXY-16ALPHA-METHYL-9ALPHA-FLUOROPREGNA-1,4-DIENE-3,20-DIONE (DEXAMETHAZONE) FROM PHYTOSTEROL	2013	Kazantsev Aleksej Vital'Evich Alexey Vitalievich) Savinova Tat'Jana Stepanovna Tatyana Stepanovna) Lukashev Nikolaj Vadimovich Nikolay Vadimovich) Dovbnja Dmitrij Vladimirovich Dmitry Vladimirovich) Khomutov Sergej Mikhajlovich Sergei Mikhailovich) Sukhodol'Skaja Galina Viktorovna Galina Viktorovna) Shutov Andrej Anatol'Evich Andrei Anatolievich) Fokina Viktorija Valer'Evna Vistoria Valerievna) Nikolaeva Vera Maksimovna Vera Maximovna) Donova Marina Viktorovna Marina Viktorovna) Egorova Ol'Ga Valer'Evna Olga Valerievna) Surovtsev Viktor Vasil'Evich Viktor Vasilievich)	RU2532902C1
METHOD OF GLUCONIC ACID SALTS AND CITRIC ACID PRODUCING	1998	Karpun E.V. Kutina N.N. Kirsanov A.T. Gorbach L.A. Chumakov S.I. Veterkhanov S.R.	RU2132878C1
	0	Matveeva Anna Konstantinovna Konyakhin Aleksandr Nikolaevich Demchenko Boris Isidorovich Voronin Vasilij Grigorevich Andreev Igor Aleksandrovich Shemeryankin Boris Vasilevich Domrachev Nikolaj Vasilevich Vasilev Viktor Nikolaevich Ioanisyan Lidiya Ilinichna	SU511946A1
METHOD OF PREPARING REICHSTAIN'S SUBSTANCE S	0	Konyakhin Aleksandr Nikolaevich Tropina Valentina Ivanovna Vasilev Viktor Nikolaevich Domrachev Nikolaj Vasilevich Demchenko Boris Isidorovich Voronin Vasilij Grigorevich Tyulyaev Ivan Ivanovich Krasnov Viktor Petrovich	SU578334A1
	0	Grinenko Galina Semenovna Ryzhkova Valentina Maksimovna Sorokina Nina Petrovna Popova Elena Viktorovna Gusarova Tatyana Ivanovna Shpingis Albina Aleksandrovna	SU555115A1

RU 2 203 953 C2

Authors

Domrachev N.V.

Dates

2003-05-10—Published

1999-11-05—Filed