DERIVATIVE OF PROTOBERBERINE SALT, 7,8-DIHYDRO- PROTOBERBERINE AND ITS SALT, ANTIFUNGAL COMPOSITIONS, METHODS FOR PREPARING BERBERINE SALTS Russian patent published in 2003 - IPC

FIELD: organic chemistry, medicine. SUBSTANCE: invention relates to novel compounds of the formula (I) and (II) that elicit antifungal activity in vitro against fungal microorganisms including cutaneous hyphomycetes, for example, Epidermophyton, Microsporum, Trichophyton, Sporothrix schenckii, Aspergillus or Candida. Compounds of formulas (I) and (II) show antifungal activity in vitro in concentrations 1-100 mcg/ml. In formulas (I) and (II) values R¹, R², R⁴ are similar or different and mean C₁-C₅-alkoxy-group; R³ means hydrogen atom or C₁-C₁₀-alkyl; A^- means inorganic acid ion, organic acid ion or halide; R⁵ means hydrogen atom, pyridylmethyl, substituted pyridylmethyl or group of the formula (XI) where Z¹, Z², Z³, Z⁴, Z⁵ are similar or different and mean independently each of other hydrogen, halogen atom, C₁-C₅-alkyl, trifluoromethyl, phenyl, substituted phenyl, nitro-group, C₁-C₄-alkoxy-group, trifluoromethoxy-group, hydroxy-group, phenoxy-group, vinyl-group, methoxycarboxyl-group. EFFECT: improved preparing methods, valuable medicinal properties of compounds. 19 cl, 5 tbl