DERIVATIVES OF 5,6-DIHYDRODIBENZO[A,G]QUINOLIZINIUM, METHOD FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2004 - IPC

FIELD: organic chemistry, chemical technology, medicine, pharmacy. SUBSTANCE: invention relates to derivatives of 5,6-dihydrodibenzo[a,g]quinolizinium of the formula (I) wherein R¹ and R² represent hydroxy-group or alkoxy-group comprising from 1 to 4 carbon atoms; or R¹ and R² represent taken together methylenedioxy-group; R³ represents hydroxy-group or alkoxy-group comprising from 1 to 4 carbon atoms; R⁴ represents alkyl group comprising from 1 to 8 carbon atoms; X represents inorganic acid ion, organic acid ion or halide, in particular, nitrate, sulfate, acetate, tartrate, maleate, succinate, citrate, fumarate, aspartate, salicylate, glycerate, ascorbate, fluoride, chloride, iodide or bromide; Z represents alkyl group comprising from 5 to 12 carbon atoms, or alkenyl group comprising from 4 to 6 carbon atoms, N-benzotriazolyl, quinolinyl, furyl with a substituent NO₂ or group represented by the formula (II) wherein Z¹, Z², Z³, Z⁴, Z⁵, A and B are such as indicated in the invention claim. Also, invention describes method for preparing these compounds and pharmaceutical composition used for hyperlipidemia treatment. Invention provides preparing new compounds eliciting valuable biological properties. EFFECT: improved preparing method, valuable medicinal properties of compounds. 17 cl, 5 tbl, 76 ex