IMIDAZOLE DERIVATIVES Russian patent published in 2005 - IPC

FIELD: organic chemistry, medicine, hormones.

SUBSTANCE: invention describes imidazole derivatives of the formula (I) , racemic-diastereomeric mixtures and optical isomers, pharmaceutical salts wherein ---- represents an optional bond; R¹ represents hydrogen atom (H), -(CH₂)_m-C(O)-(CH₂)_m-Z¹, -(CH₂)_m-Z¹; R² represents hydrogen atom (H), or R¹ and R² are joined with nitrogen atoms to which they are bound forming compounds represented by formulae (Ia), (Ib) or (Ic) wherein R³ represents -(CH₂)_m-E-(CH₂)_m-Z²; R⁴ represents hydrogen atom (H) or -(CH₂)_m-A¹; R⁵ represents (C₁-C₁₂₎-alkyl, (C₀-C₆)-alkyl-C(O)-NH-(CH₂)_m-Z³ and optionally substituted phenyl; R⁶ represents hydrogen atom (H); R⁷ represents (C₁-C₁₂)-alkyl or -(CH₂)_m-Z⁴; m = 0 or a whole number from 1 to 6; n is a whole number from 1 to 5. Proposed compounds bind with subtypes of somatostatin receptors selectively.

EFFECT: valuable properties of compounds.

20 cl, 13776 ex