FIELD: biotechnology, virology. SUBSTANCE: invention proposes DNA-construct of viable chimeric recombinant flavivirus comprising structural genes encoding proteins preM and E of virus Langat, protein C of virus Langat or mosquito virus and nonstructural genes of mosquito flavivirus. DNA-construct is used as a component of vaccine against tick-borne encephalitis virus. Vaccine against tick-borne encephalitis virus is used in method for prophylaxis of infection of human with tick-borne encephalitis virus. Vaccine provides stable protection from the following infection with tick-borne encephalitis virus. EFFECT: enhanced effectiveness of virus, valuable medicinal properties of vaccine. 15 cl, 7 tbl, 7 dwg
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