METHOD OF TREATING AND PREVENTING FIBROSIS BY IL-21/IL-21R ANTAGONISTS Russian patent published in 2011 - IPC A61K38/17 A61K39/395 A61P37/00 

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine and deals with treatment and prevention of fibrosis or fibrosis-associated states For this purpose claimed is method of introduction to patient of therapeutically efficient quantity of substance (compound), which reduces level of IL-21 and/or IL-21R Required for this purpose substance is determined by the fact of IL-21 and/or IL-21R level reduction in cells of interest or sample before and after bringing them in contact with said substance Also claimed are methods of identification of compounds for treatment, based on determination of said IL-21 and/or IL-21R level reduction Methods of monitoring progressing, as well as predicting disease course are connected with estimation dynamic of level of IL-21 and/or IL-21R in cell or sample, taken from the person at different periods of disease course time In addition, claimed is method of diagnostics by comparison of IL-21 and/or IL-21R level in cell or sample, taken from the person, with their standard level Higher IL-21 and/or IL-21R level in comparison with the standard level points to fibrosis and/or fibrosis-associated state in the person.

EFFECT: group of inventions makes it possible to detect in due time, control the course, treat successfully and prevent disease due to for the first time determined role of IL-21 and/or IL-21R in beginning and development of fibrosis of various organs and systems.

10 ex, 2 tbl, 24 dwg