FIELD: genetic engineering, medicine, pharmacy. SUBSTANCE: invention reports about the determined DNA-sequences encoding novel proteins TGF-beta of family, MP-52 and MP-121. As result of transformation of host-body cells with expression vector comprising DNA fragment with sequence encoding MP-52 an active polypeptide product eliciting ability to induce the growth of osseous and cartilage tissues is obtained. Invention provides the usage of the novel TGF-beta-like protein (MP-52) as an active component in pharmaceutical compositions designated for treatment and prophylaxis of lesions of osseous and cartilage tissues. EFFECT: improved preparing method, valuable medicinal properties of protein. 7 cl, 9 dwg, 4 ex
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