DERIVATIVES OF PYRIDAZINE, MEDICINAL AGENTS BASED ON THEREOF AND METHOD FOR TREATMENT OF ARTHRITIS Russian patent published in 2003 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to derivatives of pyridazine of the general formula (I) where R¹ means phenyl or pyridyl group that can be substituted by 1-3 substituents taken among halogen atom and lower alkoxy-groups; R² means phenyl group that can be substituted at position 4 by lower alkoxy-group, lower alkylthio-group, lower alkylsulfinyl or lower alkylsulfonyl group and by 1 or 2 substituents at other positions taken among halogen atom, lower alkoxyl groups, lower alkylthio groups, lower alkylsulfinyl groups and lower alkylsulfonyl groups; R³ means hydrogen atom, lower alkoxyl- group, halogenated lower alkyl group, lower cycloalkyl group, phenyl, pyridyl or phenyloxy-group that can be substituted by 1-3 substituents taken among halogen atoms, lower alkyl groups, lower alkoxyl groups, carboxyl group, lower alkoxycarbonyl groups, nitro-group, amino-group, lower alkylamino groups and lower alkylthio groups; piperidino-group, piperidinyl group, piperazino-group or morpholino-group that can be unsubstituted or substituted by lower alkyl group; aminocarbonyl group that can be unsubstituted or substituted by benzyl group; lower alkylcarbonyl group; or piperazinocarbonyl group that can be unsubstituted or substituted by lower alkylyl group; A means linear or branched lower alkylene or lower alkenylene group comprising 1-6 carbon atoms; or A can mean a direct linkage when R³ means lower cycloalkyl or halogenated lower alkyl group; X means oxygen or sulfur atom under condition that the following combinations are excluded: R¹ and R² mean 4-methoxyphenyl group; X means oxygen atom; A means a direct linkage and R³ means hydrogen atom or 2-chloroethyl group; or their salts. Indicated compounds are inhibitors of interleukin-1 β producing. Except for, invention relates also to medicinal agent that is inhibitor of production of interleukin-1 β, medicinal agent used for prophylaxis and treatment of patients with arthritis and method for treatment of patient with arthritis. EFFECT: valuable medicinal properties of compounds. 8 cl, 4 tbl, 172 ex