NOVEL DIAMINE CYCLIC COMPOUNDS MEDICINAL AGENTS COMPRISING THEREOF AND METHODS OF TREATMENT Russian patent published in 2003 - IPC

FIELD: organic chemistry, medicine, biochemistry, pharmacy. SUBSTANCE: invention relates to novel cyclic compounds of diamine of the formula (I) where represents optionally substituted bivalent residue of benzene where substituents are taken among unsubstituted lower alkyl group, unsubstituted lower alkoxy-group, unsubstituted lower acyl-group, acyl group, lower alkylthio-group, lower alkylsulfonyl group, halogen atom and so on, or unsubstituted pyridine; Ar represents phenyl group that can be substituted with from one to fourth groups taken among unsubstituted lower alkyl group, unsubstituted alkoxy-group, lower alkylthio-group, lower alkylsulfonyl group and so on, optionally substituted amino- group, alkylenedioxy-group; X represents NH-, oxygen or sulfur atom; Y represents sulfur atom, sulfoxide or sulfone; Z represents ordinary linkage or -NR₂-; R₂ represents hydrogen atom or unsubstituted lower alkyl group; l is a whole number 2 or 3; m is a whole number 2 or 3; n is a whole number from 1 to 3. Invention relates also to their salts or solvates. Invention relates also to pharmaceutical composition showing ACAT-inhibitory effect comprising compound of the formula (I) or its salt taken in the effective dose and pharmaceutically acceptable carrier. Invention relates also to method of treatment or prophylaxis of hyperlipemia, arteriosclerosis, cerebrovascular disturbances, ischemic cardiopathy, ischemic enteropathy or aortic aneurysm by administration of effective dose of compound of the formula (I) or its salt or solvate in patient suffering with hyperlipemia, arteriosclerosis, cerebrovascular disturbances, ischemic cardiopathy, ischemic enteropathy or aortic aneurysm. Invention provides preparing novel cyclic compounds of diamine showing ACAT-inhibitory effect. EFFECT: valuable medicinal properties of compound. 11 cl, 22 tbl, 116 ex _