CRYSTALLINE MODIFICATION OF N-TORASEMIDE, METHOD FOR ITS PREPARING, PHARMACEUTICAL FORM Russian patent published in 2003 - IPC

FIELD: organic chemistry, chemical technology, pharmacy. SUBSTANCE: invention relates to novel crystalline modification of N-torasemide N-(1-methylethylaminocarbonyl)-4-(3- methylphenylamino)-3-pyridine sulfonamide, method for its preparing in usage of controlled acidification of torasemide alkaline solutions with inorganic and organic acids with addition of seed crystals or without the latter, its usage as the initial material for preparing crystalline modification (I) of torasemide and pharmaceutically useful torasemide salts and to pharmaceutical forms also containing this novel crystalline modification of N-torasemide. EFFECT: improved preparing method. 16 cl, 4 tbl, 2 dwg, 12 ex