FIELD: medicine, veterinary science, pharmacy. SUBSTANCE: invention relates to preparing and using the preparation containing antibiotic used for treatment of topical bacterial infections in solid and soft tissues showing sustained-release of active substance. Preparing the preparation is carried out by mixing water, amphiphilic compounds taken among alkylsulfates, arylsulfates, alkylarylsulfates, cycloalkylsulfates, alkylcycloalkylsulfates, alkyl- Sulfamates, cycloalkylsulfamates, alkylcycloalkylsulfamates, arylsulfamates, alkylarylsulfamates, alkylsulfonates, fatty acid 2-sulfonates, arylsulfonates, alkylarylsulfonates, cycloalkylsulfonates, alkylcycloalkylsulfonates, alkyldisulfates, cycloalkyldisulfates, alkyldisulfonates, cycloalkyldisulfonates, aryldisulfonates, alkylaryldisulfonates, aryltrisulfonates and alkylaryltrisulfonates, one or more antibiotics among group of aminoglycoside, lincosamide and tetracycline antibiotics, accessory organic component and/or inorganic accessory component and, if necessary, one biologically active accessory component followed by preparing formed articles among powders, films, fibrillar structures and threads. Invention provides the controlled release of antibiotics for up to 3 weeks. EFFECT: improved preparing method, valuable medicinal properties of preparation. 14 cl, 1 tbl, 2 ex
