FIELD: medical facilities.
SUBSTANCE: in a preferred embodiment of invention, homogenous solution of gentamicin-pentakis-dodecyl sulfate, gentamicin-tetrakis-dodecyl sulfate, gentamicin-pentakis-dodecylsulfonate, or gentamicin-tetrakis-dodecylsulfonate is introduced into microhollows of nonmetallic materials with interconnected microhollows made from collagen or gelatin, or ester, or tricalcium phosphate, or hydroxyapatite, said solution containing methanol and/or ethanol, and/or dimethylformamide, and/or dimethylsulfoxide as solvent. Solution is introduced by immersion, spraying, and dropwise feeding. Thereafter organic solvent is vaporized and surfaces of microhollows remain coated by a layer of above-named antibiotics.
EFFECT: strengthened attachment of antibiotic coating to internal interconnected surfaced of material without closing thereof.
24 cl, 2 tbl, 2 ex
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