FIELD: virology. SUBSTANCE: invention relates to preparing German measles virus adapted to quail embryo fibroblasts. Method involves infection mixture of cells with German measles virus, strain "Orlov", consisting of primarily trypsinized renal cells of newborn rabbit and cell-fibroblasts of quail embryo followed by culturing virus and its passage. In the process of transfer from one passage to another one the content of quail embryo fibroblasts in mixture is increased and brought about to 100%. Then virus is multiplicated in 100% culture of cell-fibroblasts of quail embryo with titer from 103 to 105 TCD in 0.1 ml of cultural medium. Method allows preparing readapted German measles virus, strain "Orlov", that doesn't induce post-vaccinal responses after immunization. Except for, method allows elevating virus amount prepared in culturing. EFFECT: improved preparing method. 2 cl, 1 dwg, 3 tbl, 2 ex
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