COMBINED VACCINE FOR THE IMMUNOPROPHYLAXIS OF MEASLES, CONTAGIOUS PAROTITIS AND RUBELLA Russian patent published in 2018 - IPC A61K39/155 A61K39/165 A61K39/20 A61K47/06 A61K47/02 A61K47/18 A61K47/26 A61P31/12 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to immunology, and to a combined vaccine for the immunoprophylaxis of measles, contagious parotitis and rubella. Vaccine comprises a measles virus strain, a contagious parotitis virus strain, a rubella virus strain and a stabilizing agent. Wherein stain Leningrad-16 is used as a measles virus strain, strain Leningrad-3 is used as a contagious parotitis virus strain, wherein stain Leningrad-16 and Leningrad-3 are cultivated on trypsinized primary cells of Japanese quail embryos, strain RA27/3, cultured on the culture of human diploid cells MRC-5, is used as a rubella virus strain. Composition of the active ingredients of the vaccine per one vaccine dose comprises: measles virus – not less than 1,000 (3.0 lg) of tissue cytopathic doses (TCD₅₀); rubella virus – not less than 1,000 (3.0 lg) of TCD₅₀; parotitis virus - not less than 10,000 (4.0 lg) of TCD₅₀.

EFFECT: invention provides the possibility of producing a stable combined trivalent vaccine for the immunoprophylaxis of measles, contagious parotitis and rubella.

1 cl, 3 dwg, 3 tbl, 1 ex