FIELD: medicine, oncology. SUBSTANCE: method involves immunohistochemical study of tumor cells and investigates connexin-43 of tumor cells where amino acid sequences are determined at positions 119-142 and 363-382. Malignant progression of large intestine tumor is diagnosed in the case of detection of amino acid sequence at position 119-142 and the absence of amino acid sequence at positions 363-382. Method allows the reliable detection of initial features of malignant progression and invasive pattern of tumors of large intestine. EFFECT: improved diagnosis method. 4 ex
