FIELD: organic chemistry, pharmacology. SUBSTANCE: invention relates to novel compounds of the general formula (I) wherein a bond designated by dotted line can be a single bong, double bond or absent; if this bond is absent then nitrogen atom is substituted with hydrogen atom and R2; X represents SO2 or C=O, or CH2; Y represents
or
; oxygen atom; values R2, R3, R4, R5, R6, R7, R8 are given in the claim materials. These compounds are useful as positive modulators of AMPA- receptors that will allow their using in therapy. Invention describes also pharmaceutical composition based on the claimed compounds. EFFECT: valuable properties of compounds. 26 cl, 17 dwg, 2 tbl, 129 ex
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Authors
Dates
2003-10-20—Published
1999-02-18—Filed