FIELD: organic synthesis. SUBSTANCE: new heterocycles with general formula I: 
is provided, wherein X is carbimino group substituted by cyano group at nitrogen atom, carbonyl, or sulfonyl; Y ethylene, trimethylene, ethenylene, methylenecarbonyl or carbonylmethylene, all unsubstituted or substituted by a couple of groups RC-RD or RC-RD, and also unsubstituted carbonylimino, iminocarbonyl, methylideneimino, or iminomethylidene groups; one of Ra-RD groups signifies A-B group, in which A is group 
, 
, or 
(meanings of other radicals are presented in claim 1 of invention formula). Compounds I have antiinflammatory and bone-degradation inhibition activities and also exhibit antithrombogenic, antiaggregation, antineoplasmic, and antimetastatic effects. EFFECT: extended pharmaceutical possibilities. 6 cl, 2 tbl, 40 ex
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1996 |
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