DERIVATIVES OF 8-PYRIDONO[5,6-G]QUINOLINE, PHARMACEUTICAL COMPOSITION AND METHOD FOR CONTROL WITH THEIR USING Russian patent published in 2003 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes novel derivatives of 8-pyridono[5,6-g] quinoline of the formulas (I) , or (III) , or (IV) wherein R¹ is hydrogen, fluorine, chlorine, bromine, iodine atom; R² is CF₃CF₂H; R³ is hydrogen atom; R⁴ and R⁵ each independently means hydrogen atom, C₁-C₄-alkyl; R⁶ and mean hydrogen atom; R⁸ is hydrogen atom, C₁-C₄-alkyl; R⁹-R¹⁸ each means hydrogen atom; R¹⁹ means fluorine atom or NO₂; R²⁴ is hydrogen atom, C₁-C₄-alkyl, NO₂; R²⁵ is hydrogen atom, C₁-C₄-alkyl; R²⁶ is hydrogen atom, C₁-C₆-alkyl; R²⁷ and R²⁸ each independently means hydrogen atom or C₁-C₄-alkyl; m = 1; n = 0 or 1; o = 0 or 1; Y is oxygen atom; Z is NH, NR²²; R²² is C₁-C₄-alkyl, and also pharmaceutical composition for effect on activity of androgenic receptors. Invention describes method of effect on activity of androgenic receptors, method for modulation process mediated by androgenic receptors, method for treatment of patient involving modulation of process mediated by androgenic receptors, method for treatment of patient needing androgen-receptor therapy using derivatives of 8-pyridono[5,6-g] quinoline. Proposed compounds are antagonists and agonists of androgenic receptors and can be used in treatment and/or modulation of acnes, male baldness, hirsutism, hypogonadism, hyperplasia of prostate and hormone-dependent cancers. EFFECT: valuable medicinal properties of compounds. 36 cl, 4 tbl, 31 ex