COMPOSITIONS AND METHODS OF TREATING ANDROGEN-RECEPTOR-POSITIVE CANCER Russian patent published in 2024 - IPC A61K31/4745 A61P35/00 

FIELD: medicine.

SUBSTANCE: group of inventions relates to methods of treating breast cancer, prostate cancer and to methods of treating cancer expressing the androgen receptor. Method of treating breast cancer in a patient and a method of treating prostate cancer comprise administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition, containing a compound of formula (I)

or a pharmaceutically acceptable salt thereof, where R¹ is H or -OH; each R² is independently selected from halogen and -OR³; each R³ is independently C₁-C₆ alkyl, where alkyl is optionally substituted with one or more halogens; and n is 0, 1 or 2. Method of treating cancer expressing the androgen receptor in a patient involves administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition, containing (1R,3R)-3-[(7S)-2-[(R)-(5-fluoro-2-methoxyphenyl)(hydroxy)methyl]-6-(methoxycarbonyl)-7-methyl-3H,6H,7H,8H,9H-imidazo[4,5-f]quinolin-3-yl]cyclohexane-1-carboxylic acid or a pharmaceutically acceptable salt thereof. Method of treating cancer expressing the androgen receptor in a patient involves administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition, containing

or its pharmaceutically acceptable salt.

EFFECT: group of inventions described above allows treating breast cancer, prostate cancer and cancer expressing the androgen receptor.

36 cl, 6 dwg, 5 tbl, 12 ex