DERIVATIVE COMPOUNDS OF CARBOXYLIC ACID AND AGENTS COMPRISING THEREOF AS ACTIVE COMPONENTS Russian patent published in 2007 - IPC C07D413/14 C07D263/32 C07D417/04 C07D417/10 C07D413/04 C07D413/10 A61K31/55 A61K31/421 A61K31/496 A61K31/433 A61K31/422 A61K31/5377 A61K31/4523 A61K31/4427 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to derivative compound of carboxylic acid represented by the formula (I): , wherein each X and Y represents independently (C₁-C₄)-alkylene; Z means -O-; each R¹, R², R³ and R⁴ means independently hydrogen atom or (C₁-C₈)-alkyl; R⁵ means (C₂-C₈)-alkenyl; A means -O- or -S-; D means D¹, D², D³, D⁴ or D⁵ wherein D¹ means (C₁-C₈)-alkyl; D² means compound of the formula: wherein ring 1 represents saturated 6-membered monoheteroaryl comprising one nitrogen atom and, optionally, another one heteroatom chosen from oxygen, sulfur and nitrogen atoms; D³ means compound of the formula: wherein ring 2 represents (1) completely saturated (C₃-C₁₀)-monocarboxylic aryl, or (2) optionally saturated 5-membered monoheteroaryl comprising 3 atoms chosen from nitrogen and sulfur atoms, or completely saturated 6-membered monoheteroaryl comprising 1 heteroatom representing oxygen atom; D⁴ means compound of the formula: ; D⁵ means compound of the formula: ; R⁶ represents (1) hydrogen atom, (2) (C₁-C₈)-alkyl, (3) -NR⁷R⁸ wherein R⁷ or R⁸ represent hydrogen atom or (C₁-C₈)-alkyl, or R⁷ and R⁸ taken in common with nitrogen atom to which they are added form saturated 5-6-membered monoheteroaryl comprising one nitrogen atom and, optionally, another one heteroatom representing oxygen atom; E means -CH or nitrogen atom; m means a whole number 1-3, or its nontoxic salt. Invention relates to a regulator activated by peroxisome proliferator receptor, agent used in prophylaxis and/or treatment of diseases associated with metabolism disorders, such as diabetes mellitus, obesity, syndrome X, hypercholesterolemia or hyperlipoproteinemia, hyperlipidemia, atherosclerosis, hypertension, diseases coursing with circulation disorder, overeating or heart ischemic disease, and to an agent that increases cholesterol level associated with HDL, reduces cholesterol level associated with LDL and/or VLDL, eliminates risk factor in development of diabetes mellitus and/or syndrome X and comprising a compound represented by the formula (I) or its nontoxic salt as an active component and a carrier, excipient or solvent optionally. Invention proposes derivative compounds of carboxylic acid possessing the modulating activity with respect to peroxisome proliferator receptor (PPAR).

EFFECT: valuable medicinal properties of compounds.

15 cl, 5 tbl, 48 ex