NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVES AND MEDICAMENTS THEREOF AS ACTIVE INGREDIENT Russian patent published in 2009 - IPC C07D211/46 C07D211/74 C07D211/58 C07D211/62 C07D211/32 C07D211/66 C07D211/22 C07D211/34 C07D211/72 C07D241/04 C07D401/04 C07D401/06 C07D401/10 C07D401/14 C07D405/12 C07D409/12 C07D413/12 C07D487/08 A61K31/403 A61K31/55 A61K31/4468 A61K31/4545 A61K31/4709 A61K31/497 A61P11/06 A61P31/18 A61P37/00 

FIELD: chemistry.

SUBSTANCE: present invention refers to the new compounds of formula (I): whereat R¹ is -SO₂NR¹⁰²R¹⁰³, -NR¹⁰¹SO₂R¹⁰⁴ or -COOR¹⁰⁵ whereat R¹⁰¹ is hydrogen atom, R¹⁰² and R¹⁰³ each independently represents hydrogen atom or C1-4 alkyl, R¹⁰⁴ is C1-4 alkyl and R¹⁰⁵ is hydrogen atom or C1-4 alkyl ; X is bond, -CH₂- or -O-; Y is -CH₂-; ring A and ring B, which are same or different, each independently is benzene, pyridine, pyrazol or piperidine which can have the following substituents: C1-4 alkyl or halogen; ring D is piperidine; R² is whereat the arrow shows the position of the bond with the ring D; R⁵¹ is (1) hydrogen atom a, (2) C1-6alkyl, which can have the following substituents: (a) hydroxy, (b) methoxy, (c) cyano, (d) carboxy, (e) halogen, (f) methyl sulphonylamino, (g) C3-8cycloalkyl or phenyl, which can have the following substituents: methyl, halogen, hydroxy or methoxy, (h) thienyl, pyrazolyl, tetrahydropyranyl, thiazolyl, isooxalyl, imidazolyl, tetraazolyl, pyridyl, pyrimidinyl which can have the following substituents: methyl, trifluoromethyl or hydroxy, (3) C2-10alkenyl, (4) C2-10alkynyl, (5) phenyl which can have the following substituents: C1-4alkyl or halogen, or (6) pyridine or tetrahydropyran; R⁵² is (1) hydrogen atom a, (2) C1-6alkyl which can have the following substituents: (a) hydroxy, (b) methoxy, (c) carboxy, (d) C3-8cycloalkyl, (e) phenyl or (f) oxo, (3) C3-8cycloalkyl or phenyl which can have the following substituents: C1-4alkyl, hydroxy, cyano, oxo, carbamoyl, N-methyl aminocarbonyl, carboxy, halogen, methoxy, trifluoromethoxy, methythio, methylsulphonyl, acetylamino, dimethylamino, acetyl, tetraazolyl, trifluoromethyl or methylsulphonylamino (4) C3-10cycloalkenyl, (5) adamantyl, (6) thienyl, pyrazolyl, tetrahydropyranyl, isoxaazolyl, isothiazolyl, thiadiazolyl, piperidinyl, pyridyl, pyrimidinyl, pyridazinyl, quinolyl, indolyl, benzothiazolyl, benzoisothiazolyl, benzotriazolyl, dioxaindanyl, benzodioxaindanyl which can have the following substituents: C1-4alkyl, hydroxy, oxo, halogen, azido or trifluoromethyl or (7) benzyloxy groups; and R⁵³ is hydrogen atom or C1-6alkyl; to its salts or its solvates. The invention refers also to the regulator CCR5, to the agent of prevention and/or treatment of HIV infection, immunological or inflammatory diseases, to the pharmaceutical composition, to the medicinal preparation, to the method of disease treatment or prevention as well as to the application of compound as in claim 1.

EFFECT: obtaining of new bioactive compounds possessing anti CCR5 receptor activity.

23 cl, 41 ex