PHENYLACETIC ACID COMPOUNDS Russian patent published in 2012 - IPC C07D265/36 A61K31/538 A61K45/00 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula (I-a), pharmaceutically acceptable salts, N-oxides, solvates and prodrugs, and a pharmaceutical composition based on said compounds. The compounds have DP receptor antagonist properties and can be used to treat diseases mediated by activity thereof, such as allergic rhinitis, atopic dermatitis, bronchial asthma and food allergy. In general formula (I-a) R¹ is a hydrogen atom or a C_1-4 alkyl group, each R⁴, R⁵ and R⁶ independently denotes methyl or ethyl, indicates that the substitute protrudes from the plane of the page, m is O, n is an integer from 1 to 2 and i is O, under the condition that when n equals 2, R⁵ can be identical or different.

EFFECT: improved method.

6 cl, 3 dwg, 31 ex