AGONISTS OF APOLIPOPROTEIN A-I AND THEIR USING FOR TREATMENT OF DYSLIPIDEMIA-MEDIATED DISEASES Russian patent published in 2003 - IPC

FIELD: organic chemistry, peptides, medicine, pharmacy. SUBSTANCE: invention relates to agonist of ApoA-I including peptide or peptide analogue comprising from 15 to 29 amino acid residues that forms amphipathic α-helix in the presence of lipids and that is characterized by the following formula: or its pharmaceutically acceptable salt. Values of radicals see in the invention claim. Compounds show high agonistic activity with respect to apolipoprotein A-I and can be used for treatment of diseases associated with dyslipoproteinemia including hypercholesterolemia, cardiovascular diseases, atherosclerosis, restenosis and septic shock. Invention describes multiple agonist of ApoA-I, complex of agonist of ApoA-I and lipid, pharmaceutical compositions comprising compounds proposed and method for treatment using agonists of ApoA-I. EFFECT: valuable medicinal properties of agonists. 62 cl, 18 tbl, 31 dwg