GENE-THERAPEUTIC METHODS FOR ADMINISTRATION OF APOLIPOPROTEIN A-1 AGONISTS AND THEIR USING IN TREATMENT OF DYSLIPIDEMIC DISORDERS Russian patent published in 2004 - IPC

FIELD: molecular biology, genetic therapy, medicine, amino acids. SUBSTANCE: invention relates to nucleotide sequence encoding agonist of ApoA-1 comprising the following components: (i) 15-29 amino acid peptide that forms amphipathic α-helix in the presence of lipids and showing structural formula (I): or its pharmaceutically acceptable salt wherein X₁ represents Pro (P), Ala (A), Gly (G), Gln (Q), Asn (N) or Asp (D); X₂ represents aliphatic residue; X₃ represents Leu (L) or Phe (F); X₄ represents acid residue; X₅ represents Leu (L) or Phe (F); X₆ represents Leu (L) or Phe (F); X₇ represents hydrophilic residue; X₈ represents acid or basic residue; X₉ represents Leu (L) or Gly (G); X₁₀ represents Leu (L), Trp (W) or Gly (G); X₁₁ represents hydrophilic residue; X₁₂ represents hydrophobic residue;X₁₃ represents Gly (G) or aliphatic residue; X₁₄ represents Leu (L), Trp (W) or Gly (G); X₁₅ represents hydrophilic residue; X₁₆ represents hydrophobic residue; X₁₇ represents hydrophobic residue; X₁₈ represents Gln (Q), Asn (N) or basic residue; X₁₉ represents Gln (Q), Asn (N) or basic residue; X₂₀ represents basic residue; X₂₁ represents aliphatic residue; X₂₂ represents basic residue; X₂₃ is absent or represents basic residue; or (ii) deleted form of structural formula (I) wherein 1-8 residues among are deleted; or (iii) alternated form of structural formula (I) wherein at least one residue among is substituted for another residue by conservative mechanism. Compounds are useful for treatment of diseases associated with dyslipidemia. Invention describes also methods for preparing peptide encoded by these nucleotide sequences, pharmaceutical compositions containing thereof and methods for treatment of diseases associated with dyslipidemia. EFFECT: valuable medicinal properties of peptides, enhanced effectiveness of disease treatment. 68 cl, 10 tbl, 5 dwg, 6 ex