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2 434 880

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IPC

C07K14/00(2006-01-01)

A61K38/16(2006-01-01)

A61P31/04(2006-01-01)

(21) (22)

Application

2010130096/10, 2010-07-21

(24)

Start date

2010-07-21

(22)

Actual filing date

2010-07-21

(45)

Published

2011-11-27

(72)

Inventor

Pinegin Boris VladimirovichZhmak Maksim NurgajanovichBudikhina Anna SergeevnaFedenko Elena SergeevnaMakarov Evgenij Anatol'Evich

(73)

Holder

Obshchestvo S Ogranichennoj Otvetstvennost'Ju

POLYPEPTIDE DEMONSTRATING ANTIBACTERIAL ACTIVITY AND SUITABLE FOR OBTAINING THERAPEUTIC MEDICATIONS FOR TREATMENT OF HUMAN BACTERIAL INFECTIONS Russian patent published in 2011 - IPC C07K14/00 A61K38/16 A61P31/04

Abstract RU 2434880 C1

FIELD: medicine.

SUBSTANCE: obtained is polypeptide of the following formula: U-X₁₉-X₂₀-X₂₁-X₂₂-X₂₃-X₂₄-X₂₅-X₂₆-X₂₇-X₂₈-X₂₉-X₃₀-X₃₁-X₃₂-Z, with U=X₁₈, X₁₇-X₁₈, X₁₆-X₁₇-X₁₈, X₁₅-X₁₆-X₁₇-X₁₈, X₁₄-X₁₅-X₁₆-X₁₇-X₁₈, X₁₃-X₁₄-X₁₅-X₁₆-X₁₇-X₁₈, X₁₂-X₁₃-X₁₄-X₁₅-X₁₆-X₁₇-X₁₈, X₁₁-X₁₂-X₁₃-X₁₄-X₁₅-X₁₆-X₁₇-X₁₈, X₁₀-X₁₁-X₁₂-X₁₃-X₁₄-X₁₅-X₁₆-X₁₇-X₁₈, X₉-X₁₀-X₁₁-X₁₂-X₁₃-X₁₄-X₁₅-X₁₆-X₁₇-X₁₈, X₈-X₉-X₁₀-X₁₁-X₁₂-X₁₃-X₁₄-X₁₅-X₁₆-X₁₇-X₁₈, X₇-X₈-X₉-X₁₀-X₁₁-X₁₂-X₁₃-X₁₄-X₁₅-X₁₆-X₁₇-X₁₈, X₆-X₇-X₈-X₉-X₁₀-X₁₁-X₁₂-X₁₃-X₁₄-X₁₅-X₁₆-X₁₇-X₁₈, X₅-X₆-X₇-X₈- X₉-X₁₀-X₁₁-X₁₂-X₁₃-X₁₄-X₁₅-X₁₆-X₁₇-X₁₈, X₄-X₅-X₆-X₇-X₈- X₉-X₁₀-X₁₁-X₁₂-X₁₃-X₁₄-X₁₅-X₁₆-X₁₇-X₁₈, X₃-X₄-X₅-X₆-X₇-X₈- X₉-X₁₀-X₁₁-X₁₂-X₁₃-X₁₄-X₁₅-X₁₆-X₁₇-X₁₈, X₂-X₃-X₄-X₅-X₆-X₇-X₈- X₉-X₁₀-X₁₁-X₁₂-X₁₃-X₁₄-X₁₅-X₁₆-X₁₇-X₁₈ or X₁-X₂-X₃-X₄-X₅-X₆-X₇-X₈- X₉-X₁₀-X₁₁-X₁₂-X₁₃-X₁₄-X₁₅-X₁₆-X₁₇-X₁₈; Z=X₃₃, X₃₃-X₃₄, X₃₃-X₃₄-X₃₅, X₃₃-X₃₄-X₃₅-X₃₆, X₃₃-X₃₄-X₃₅-X₃₆-X₃₇, X₃₃-X₃₄-X₃₅-X₃₆-X₃₇-X₃₈, X₃₃-X₃₄-X₃₅-X₃₆-X₃₇-X₃₈-X₃₉, X₃₃-X₃₄-X₃₅-X₃₆-X₃₇-X₃₈-X₃₉-X₄₀ or X₃₃-X₃₄-X₃₅-X₃₆-X₃₇-X₃₈-X₃₉-X₄₀-X₄₁; X₁=Ser; X₂=Glu; X₃=Thr; X₄=Arg; X₅=Pro; X₆=Val; X₇=Leu; X₈=Asn; X₉=Arg; X₁₀=Leu; X₁₁=Phe; X₁₂=Asp; X₁₃=Lys; X₁₄=Ile; X₁₅=Arg; X₁₆=Gln; X₁₇=Val; X₁₈=Ile; X₁₉=Arg; X₂₀=Lys; X₂₁=Phe; X₂₂=Glu; X₂₃=Lys; X₂₄=Gly; X₂₅=Ile; X₂₆=Lys; X₂₇=Glu; X₂₈=Lys; X₂₉=Ser; X₃₀=Lys; X₃₁=Arg; X₃₂=Phe; X₃₃=Phe; X₃₄=Asp; X₃₅=Gly; X₃₆=Leu; X₃₇=Leu; X₃₈=Ala; X₃₉=Phe; X₄₀=Arg; X₄₁=Lys.

EFFECT: invention makes it possible to obtain polypeptide, efficient in treatment and prevention of human bacterial infections.

8 cl, 2 dwg, 17 tbl, 6 ex

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RU 2 434 880 C1

Authors

Pinegin Boris Vladimirovich

Zhmak Maksim Nurgajanovich

Budikhina Anna Sergeevna

Fedenko Elena Sergeevna

Makarov Evgenij Anatol'Evich

Dates

2011-11-27—Published

2010-07-21—Filed