PARA-TERPHENYL COMPOUNDS, METHOD OF THEIR SYNTHESIS (VERSIONS) AND PHARMACEUTICAL COMPOSITION (VERSIONS) Russian patent published in 2003 - IPC

FIELD: organic chemistry, chemical technology, pharmacy. SUBSTANCE: invention relates to novel para- -terphenyl compounds of the formula (I) or their pharmaceutically acceptable salts or hydrates that elicit immunosuppressive and antiallergic effect, in part, they elicit IgE-selective producing suppressive activity, to method of their synthesis and pharmaceutical compositions based on thereof. In compounds of the formula (I) X means -O-, -CH₂-, -NR¹⁴ where R¹⁴ means hydrogen atom, optionally substituted lower alkyl, optionally substituted alkenyl or acetyl, or -S(O)_p where p means a whole number from 0 to 2; Y means hydrogen atom, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted acyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl; Y can mean optionally substituted lower alkoxy-group if X means -CH₂- and can mean optionally substituted lower alkoxycarbonyl, optionally substituted lower alkylsulfonyl or optionally substituted arylsulfonyl if X means -O- or -NR¹⁴; R¹-R¹³ can mean different values indicated in the invention claim, for example, R¹ and R²; R¹ and R⁴; R⁶ and R⁷; R⁸ and R⁹, R¹¹ and -X-Y or R¹³ and -X-Y taken in common can form 5- or 6-membered ring that can comprise one or more atoms taken among O, S or NR¹⁵. Methods of synthesis of compounds of the formula (I) involve interaction of different phenyl fragments corresponding to fragments of the formula (I). Pharmaceutical compositions comprise compounds of the formula (I), its pharmaceutically acceptable salt or hydrate and pharmaceutically acceptable vehicle. EFFECT: improved methods of synthesis, valuable medicinal properties of compounds. 15 cl, 4 dwg, 334 tbl