FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention describes piperazine-cyclodextrin complex formed by 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl] -ethyl] -5,6-dimethoxy-1-(4- imidazolylmethyl)- -1H- indazole and water-soluble derivative of cyclodextrin where indicated derivative of cyclodextrin represents sulfobutyl-β--cyclodextrin either hydroxyl-β-cyclodextrin or its salt. Invention describes also agent for treatment of diseases of circulation and brain diseases that comprises above indicated complex as an active component. Complex shows high solubility in water and low topical irritating effect. EFFECT: improved and valuable medicinal properties of complex. 13 cl, 3 tbl
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CRYSTALLINE 3[-2[4-(3-CHLORO-2-METHYLPHENYL)-1- PIPERAZINYL]ETHYL]-5,6-DIMETHOXY-1-[4-IMIDAZOLYLMETHYL]- 1H-INDAZOLE DEHYDROCHLORIDE AND 3,5-HYDRATE THEREOF, AND METHODS OF PREPARATION THEREOF | 1995 |
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Authors
Dates
2003-11-20—Published
1998-10-29—Filed