SULFONAMIDE DERIVATIVE, MEDICINAL AGENT, METHODS FOR TREATMENT Russian patent published in 2003 - IPC

FIELD: organic chemistry, biochemistry, medicine. SUBSTANCE: invention relates to sulfonamide compound of the formula (I) eliciting effect that inhibits activity of matrix metalloproteinase-13 and aglycanase wherein R¹ is NHOH; R² is group -A- R⁶ wherein A is C₁-C₆-alkylene; R⁶ group of the formula (II) wherein X is group -N(R¹⁰)-; R⁷ and R⁸ are similar or different and mean hydrogen atom, C₁-C₆-alkyl, COOH, lower alkoxy-group, halogen atom, phenyl; or R⁷ and R⁸ in common with carbon atom to which they are bound form unsaturated C₃-C₇-ring, aryl-C₆-C₁₀, heteroaryl-C₅-C₇ comprising 1 or 2 ring nitrogen or sulfur atoms; R¹⁰ is hydrogen atom, C_1-6-alkyl; R³ is hydrogen atom, C_1-6-alkyl possibly substituted with halogen atom, phenyl, in turn, optionally substituted with halogen atom, or alkynyl-C_3-10; R⁴ is phenylene; R⁵ is C_1-6-alkyl optionally substituted with at least one halogen atom, 5- or 6-membered heteroaryl comprising 1 or 2 nitrogen atoms, phenyl optionally substituted with at least one halogen atom. Compounds of the formula (I) are useful for treatment of arthritis or osteoarthritis. EFFECT: valuable medicinal properties of compound. 18 cl, 11 tbl, 173 ex