DERIVATIVES OF SPIROPIPERIDINE, MEDICINAL AGENT, METHOD OF PROPHYLAXIS OR TREATMENT Russian patent published in 2002 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to novel derivatives of spiropiperidine of the general formula (I) where R¹ means phenyl group that can be optionally substituted with 1-3 substituents taken among halogen atoms, lower alkyl groups, halogen-lower alkyl groups, lower alkoxy-groups, lower alkoxycarbonyl group, hydroxyl groups, lower aliphatic acylamino-groups, cyano-groups or 5- or 6-membered heterocyclic group comprising 1-3 oxygen, sulfur and/or nitrogen atoms that can be optionally condensed with phenyl group; R² means phenyl group that is substituted with 1-3 fluorine or chlorine atoms; A means carbonyl group; B means an ordinary bond; D means oxygen or sulfur atom; E means C_1-4-alkylene group; means the group of the formula (II) where G means C_5-8-alkane ring substituted with hydroxyl group; Ar means phenyl ring; n is a whole number 1 or 2; or their pharmacologically acceptable alts. Invention relates to also a medicinal agent showing an antagonistic effect with respect to NK₁-, NK₂- and NK₃-receptors and containing compound of the formula (I) or its pharmacologically acceptable salt as an effective component and excipient. Proposed compounds can be used for treatment or prophylaxis of disease that can be treated or prevented with agents showing an antagonistic effect with respect to NK₁-, NK₂- and NK₃-receptors by administration of compound of the formula (I) or its pharmacologically acceptable salt in warm-blooded animal in effective dose. EFFECT: new derivatives of spiropiperidine indicated above, valuable pharmacological properties. 12 cl, 3 tbl