CYCLOBUTENE DERIVATIVES Russian patent published in 2002 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to compounds of the formula (I) where R¹ and R² mean cycloalkyl group, aryl group, heterocyclic group; R³ and R⁴ mean hydrogen atom or alkyl group; R⁵ means hydrogen atom, alkyl; R⁶ means hydroxy-group, alkylthio-group or amine residue; X and Y mean oxygen atom; Z means a single bond between indicated nitrogen atom and benzene ring or alkylene group; G means a direct bond, alkyl, alkylene; dotted line means a single or double bond; D means carbon atom and E means the group =N-O. These compounds show inhibitory activity against bile acids and therefore they can be used for preparing drug for inhibition of bile acid carrier in jejunum and for treatment and prophylaxis of hyperchlolesterolemia. EFFECT: valuable medicinal properties of compounds. (I) , 46 cl, 8 tbl, 141 ex