POLYCYCLIC DIHYDROTHIAZOLES, ANOREXIC MEDICINAL AGENT AND METHOD FOR IT PREPARING Russian patent published in 2003 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to new poly- cyclic dihydrothiazoles of the general formula (I) wherein Y means simple bond; X means CH₂; R1 means hydrogen, fluorine, chlorine atom, NO₂, CN, COOH, (C₁-C₆)-alkyl, (C₂-C₆)-alkynyl, O-(C₁-C₆)-alkyl being one, some or all hydrogen atoms in alkyl residues can be substituted with fluorine atom; (CH₂)_n-phenyl, SO₂-(C₁-C₆)-alkyl being n = 0 and phenyl residue can be mono- and disubstituted with fluorine, chlorine atom, CF₃, OCF₃, O-(C₁-C₆)- alkyl, (C₁-C₆)-alkyl; O-(CH₂)_n-phenyl being n = 0 and phenyl cycle can be mono- and disubstituted with chlorine atom, (C₁-C₆)-alkyl; 1- or 2-naphthyl, 2- or 3- thienyl; R1' means hydrogen atom; R2 means hydrogen atom, (C₁-C₆)-alkyl; R3 means hydrogen atom; R4 means (C₁-C₈)-alkyl, (C₃-C₇)-cycloalkyl, (CH₂)_n-aryl being n = 0-1 and aryl can represent phenyl, 2-, 3- or 4-pyridyl, 2- or 3-thienyl, 2- or 3-furyl, indole-3-yl, indole-5-yl being aryl residue or heteroaryl residue can be mono- or disubstituted with fluorine, chlorine atom, OH, OCF₃, O-(C₁-C₆)- alkyl, (C₁-C₆)-alkyl, 2-, 3-, 4-pyridyl, pyrrole-1-yl and pyridyl ring can be substituted with CF₃; and also their physiologically acceptable salts. Medicinal agent eliciting anorexic effect comprises one or some compounds of the formula (I) as biologically active substance and pharmaceutically acceptable carrier. Invention relates also to method for preparing medicinal agent eliciting anorexic effect where one or some compounds of the formula (I) as biologically active substance are mixed with pharmaceutically acceptable carrier and this mixture is brought about to form suitable for administration. Claimed compounds can be used as medicinal agent for prophylaxis or treatment of obesity. Invention provides preparing new compounds eliciting anorexic effect. EFFECT: improved preparing method, valuable medicinal properties of compounds. 6 cl, 2 tbl, 24 ex