INDENO-, NAPHTHO-, AND BENZOCYCLOHEPTADIHYDROTHIAZOLE DERIVATIVES, PRODUCTION THEREOF AND USES AS ANOREXIA PHARMACEUTICALS Russian patent published in 2005 - IPC

FIELD: organic chemistry, pharmacology.

SUBSTANCE: invention relates to polycyclic dihydrothiazoles of formula I , containing in substituted alkyl residues in 2-posiiton, as well as physiologically accepted salts thereos, having anorexia action. In formula Y is direct bond; X is CH₂; R1 and R1' are independently H, Cl; R2 and R3 are H; R4 is (C₈-C₁₆-cycloalkyl, (CH₂)n-A-R8, wherein n = 1-6, excepted group of formula -CH₂-O-CH₂-phenyl with unsubstituted phenyl; A is O, S; R8 is methyl or (CH₂)_m-aryl, where in m = 0-6; and aryl may represent phenyl, wherein aryl group may be optionally substituted with one or two substituents, selected from Cl, O-(C₁-C₆)-alkyl or (C₁-C₆)-alkyl. Also disclosed is method for production thereof.

EFFECT: new anorexia pharmaceuticals.

5 cl, 4 ex, 2 tbl