NEW CYTOTOXIC MACROLIDES COMPRISING TRIS(OXAZOL), METHOD FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHODS FOR TREATMENT Russian patent published in 2003 - IPC

FIELD: organic chemistry, chemical technology, medicine, pharmacy. SUBSTANCE: invention relates to new cytotoxic macrolide compound of the formula (I) wherein X represents lower alkyl; R¹ and R² represent hydrogen atom or lower alkyl; R^3a represents hydrogen atom; R^3b represents compounds of the formula (II) or (III) or R^3a and R^3b in common represent oxygen atom; R⁴ represents hydrogen atom, hydroxy-group, lower alkoxy-group and so on; R⁵ represents hydrogen atom, carbamoyl and so on; R^6a represents hydrogen atom; R^6b represents hydroxy-group either R^6a and R^6b in common represent oxygen atom; R⁷ represents hydrogen atom and so on; R⁸ represents lower alkoxy- group and so on; Y¹ represents hydrogen atom or methyl; Y² represents hydrogen atom or Y¹ and Y² in common represent double bond being in definitions of groups of the formula (I) lower alkyl and lower alkyl fragment of lower alkanoyl or lower alkoxy-group means linear or branched alkyl group comprising 1-6 carbon atoms, such as methyl, ethyl and so on. Invention relates to method for treatment of mammals damaged with malignant tumor sensitive to compound of the formula (I) and involving administration to the damaged individual therapeutically effective dose of indicated compound or its pharmaceutical composition. Invention relates to pharmaceutical preparation eliciting antitumor effect containing compound of the formula (I) as an active component and a carrier. Invention relates to method for preparing compound of the formula (I) that involves treatment of the known Kabiramides taken among Kabiramide B or C with acid, respectively, in suitable solvent. Invention provides preparing new compound eliciting an antitumor effect. EFFECT: improved preparing method, valuable medicinal properties of macrolides. 10 cl, 1 tbl