ALKALOIDS, METHOD FOR THEIR PREPARING, METHOD FOR TREATMENT, PHARMACEUTICAL COMPOSITION Russian patent published in 2004 - IPC

FIELD: organic chemistry of natural compounds, pharmacy. SUBSTANCE: invention relates to new cytotoxic diterpene alkaloids of formulas (I) or (II) wherein R¹ is hydrogen atom, lower alkyl or lower alkanoyl; R² is hydrogen atom, lower alkyl; R³ is alkyl comprising one or more isoprene residues; R⁴ and R⁵ mean hydrogen atom or lower alkyl; R⁶ is lower alkyl; X means fluorine, chlorine, bromine or iodine atom, lower alkyl or lower alkanoyl (branched or unbranched). Compounds of formulas (I) and (II) are isolated from sponge Raspalia sp. by extraction followed by chromatography using suitable solvent and eluting agent. EFFECT: improved preparing method, valuable medicinal properties of alkaloids. 10 cl, 3 tbl, 1 ex