ARYLPIPERAZINE DERIVATIVES, METHODS FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD FOR TREATMENT Russian patent published in 2004 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to new arylpiperazine derivatives of the general formula (I): and their pharmaceutically acceptable salts and esters wherein Y represents oxygen atom; Q represents CH; X, Z and Z' each represents independently CH or nitrogen atom; m = 0-1; n = 0-4; R₁ and R₂ are taken independently among of: hydrogen, fluorine, chlorine, bromine atom, OCH₃, OCH₂H₅, OCH₂CF₃, CH₃, C₂H₅, CF₃, isopropyloxy-group; R₃ represents hydrogen atom; R₄ and R₅ represent hydrogen atom or phenyl with exception that R₁ represents Hydrogen atom; R₂ represents hydrogen, chlorine atom or CF₃; R₃,R₄,R₅ mean hydrogen atom; Y means oxygen atom; Q means CH if m = 0 and n = 1; and with exception that R₁ represents hydrogen atom; R₂ represents OCH₃; R₃,R₄,R₅ mean hydrogen atom; Y means oxygen atom; Q means CH if m = 0 and n = 2. Invention relates also to methods for preparing these compounds, pharmaceutical composition based on thereof eliciting uroselective antagonistic activity with respect to α₁- -adrenoceptors and to methods for treatment of beneath prostate hypertrophy, vascular diseases, congested cardiac insufficiency and hypertension. Invention provides preparing new compounds eliciting valuable pharmaceutical properties. EFFECT: improved preparing methods, enhanced treatment methods, valuable medicinal properties of compounds. 27 cl, 6 tbl